If a response is obtained, the dose can be reduced to 1, mg of glucosamine and mg of chondroitin per day. According to the Tufts study, it is still unclear as to whether higher doses are more effective and whether that level of dosing may cause potential harm.
Because supplements are not regulated by the Food and Drug Administration, the amount of active ingredient cannot always be verified. Most studies have shown that glucosamine needs to be taken for two to four months before its full benefits are realized, although some will experience improvement sooner. Potential side effects of glucosamine-chondroitin include:.
These risks may increase at higher doses. Glucosamine should be avoided if you are allergic to shellfish. People on the blood thinner Coumadin warfarin may have an increased risk of bleeding. Stop treatment and call your healthcare provider if you experience sudden swelling in the legs or irregular heartbeats. Call or seek emergency care if you develop hives, shortness of breath, rapid heartbeats, or the swelling of the face, tongue, or throat. Always consult your own healthcare provider.
Your healthcare provider knows your medical history and your current medication regimen. Make your healthcare provider aware that you wish to add a supplement to your treatment regimen, then follow their advice. For some people, yes. One notable study of glucosamine and chondroitin found the supplement combo helps to reduce pain, stiffness, functional limitations, and joint swelling as effectively as the prescription anti-inflammatory drug Celebrex celecoxib.
In general, yes, glucosamine and chondroitin are safe to take in doses listed on the supplement label. However, people who are allergic to shellfish should not take glucosamine. In addition, taking this supplement with the blood thinner Coumadin warfarin may increase the risk of bleeding. Glucosamine and chondroitin can cause gastrointestinal side effects, such as bloating, constipation, diarrhea, gas, nausea, and stomach pain.
The supplement combo may also cause puffy eyes and hair loss. Glucosamine and chondroitin are both dietary supplements that may help decrease the pain of osteoarthritis in some patients.
It has been suggested that they may help cartilage nutrition or they may help by decreasing inflammation. Studies using humans have produced much more variable results.
Some have shown that glucosamine and chondroitin have no effect, some have shown that they decrease pain and inflammation, and some have shown that they can slow negative physical changes. Because of this, you need to take a fairly large dose to have any effect. For most patients, Dr Prodromos recommends starting by taking mg of glucosamine and mg of chondroitin each day. If after 2 weeks, you have not felt any improvement and are not experiencing any side effects and you weigh lbs or more, you can increase your dose of glucosamine.
You can take 20 mg of glucosamine for every 2. This means that: If you weigh lbs, you should take mg of glucosamine a day. If you weigh lbs, you can take mg a day. They are also available as dietary supplements. Researchers have studied the effects of these supplements, individually or in combination, on osteoarthritis, a common type of arthritis that destroys cartilage in the joints.
Cartilage is the connective tissue that cushions the ends of bones within the joints. In osteoarthritis, the surface layer of cartilage between the bones of a joint wears down. This allows the bones to rub together, which can cause pain and swelling and make it difficult to move the joint. The knees, hips, spine, and hands are the parts of the body most likely to be affected by osteoarthritis. For more information about osteoarthritis, visit the National Institute of Arthritis and Musculoskeletal and Skin Diseases Web site at www.
In general, research on chondroitin has not shown it to be helpful for pain from knee or hip osteoarthritis. A few studies have looked at whether glucosamine or chondroitin can have beneficial effects on joint structure.
Some but not all studies found evidence that chondroitin might help, but the improvements may be too small to make a difference to patients. There is little evidence that glucosamine has beneficial effects on joint structure. Experts disagree on whether glucosamine and chondroitin may help knee and hip osteoarthritis.
The American College of Rheumatology ACR has recommended that people with knee or hip osteoarthritis not use glucosamine or chondroitin. But the recommendation was not a strong one, and the ACR acknowledged that it was controversial.
Only a small amount of research has been done on glucosamine and chondroitin for osteoarthritis of joints other than the knee and hip. Because there have been only a few relatively small studies, no definite conclusions can be reached. The U. Food and Drug Administration regulates dietary supplements, but the regulations for dietary supplements are different and less strict than those for prescription or over-the-counter drugs.
Some dietary supplements may interact with medications or pose risks if you have medical problems or are going to have surgery. Most dietary supplements have not been tested in pregnant women, nursing mothers, or children. For more information, see Using Dietary Supplements Wisely. Glucosamine therapy for treating osteoarthritis.
Cochrane Database of Systematic Reviews. Accessed at www. This publication is not copyrighted and is in the public domain. Duplication is encouraged. Despite their widespread use, glucosamine and chondroitin are controversial when used to treat osteoarthritis pain, due to conflicting research and recommendations.
There are many studies available on the use of glucosamine and chondroitin for osteoarthritis pain, though they have conflicting conclusions on the effectiveness of the supplements. Glucosamine has been extensively studied for its role in osteoarthritis pain management. In a analysis in 1, people with hip or knee osteoarthritis, glucosamine supplements did not significantly improve osteoarthritis pain or function compared with a placebo 6.
On the other hand, a analysis showed small improvements in knee osteoarthritis pain with regular use of glucosamine sulfate, though the authors suggested that higher-quality data is needed 7. After 6 months, chondroitin sulfate led to similar pain scores as celecoxib and significantly lower scores than the placebo. Thus, the authors concluded that chondroitin sulfate may be an effective pain remedy for those with knee osteoarthritis pain However, the overall quality of studies was low In the same review, the supplement was not found to improve joint mobility or function compared with a placebo Though the two can be taken separately, glucosamine and chondroitin are commonly taken as a single supplement.
This combination has been more extensively studied. Meanwhile, chondroitin alone led to minor improvements in pain On the other hand, another analysis observed a significant improvement in pain scores when glucosamine and chondroitin were taken together, while no improvements were found when the supplements were taken separately Similarly, a sponsored study showed that combining 1, mg of glucosamine hydrochloride with 1, mg of chondroitin sulfate effectively reduced knee osteoarthritis pain, stiffness, and swelling compared with mg of the osteoarthritis NSAID celecoxib Another study also found that combined glucosamine and chondroitin supplements were comparably effective as celecoxib
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